yes, of course. i dont see why not! if your just gonna take it out like you do to make a slim case or something. plus you can have two hdds and a dvd drive anyway, so yeah you could beat palmores record of 4 hdds and put like 5! haha two above the psu and part of the mobo, by where the original hdd goes, two ontop of each other where the dvd drive is, and 1 in the back by where the back of the dvd drive used to be. do i think you can have 5 hdds, will your xbox be able to do that? i would say no, but im really bored and i rampling on is fun! so in conclusion i would have to say yes you can, jus a some more fans. and oh yeah, post pix when you done, if you do it!